Ideal for sterile eye drop production in pharmaceutical, biotech, and ophthalmic industries, including preservative-free eye drops, artificial tears, dry eye relief solutions, antibiotic eye drops, anti-allergic eye drops, post-ophthalmic surgery care solutions, and other sensitive ophthalmic formulations. It is also suitable for small-volume sterile liquid products such as sterile serum\u00a0and biological reagents, supporting both single-dose ampoules and multi-dose bottles production.<\/p>\n
THE RELIANCE RVFE sterile eye drop filling, plugging, and capping machine is a high-performance, fully automated production solution exclusively for sterile ophthalmic formulations. Engineered to meet the GMP, FDA 21 CFR Part 11, and EU GMP standards, this all-in-one machine integrates automatic bottle unscrambling, fill, plugger-in, and torque-controlled capping, 15\u2033 HMI, all servo drive system, high precision ceramic pump, preservative-free ophthalmic solutions, and sensitive eye care products.<\/p>\n
Designed for large-scale and high-precision production, the machine adopts advanced servo-driven technology and ISO 5 (Class 100) cleanroom-compatible design, ensuring every bottle of eye drop meets the highest sterility and quality standards. It is fully compatible with various bottle sizes (3ml\/5ml\/10ml\/15ml) and cap types (dropper caps, screw caps, tamper-evident caps), supporting both single-dose and multi-dose sterile eye drop production, and can be easily integrated into existing ophthalmic production lines for maximum operational flexibility.<\/p>\n
Sterile Eye Drop Filling Machine, Monoblock Filling, Aseptic Eye Drops Filling, Filling Stoppering Capping, Reliance Machinery<\/p>\n
\u2705 Fully Automatic & Aseptic Operation \u2013 Integrates bottle unscrambling, filling, stoppering, capping, and quality inspection in one automated line; closed-loop design with A\u7ea7 laminar flow\/RABS isolation and BFS sterile filling option, ensuring 100% sterile, pyrogen-free production without contamination risk. \u2705 GMP & FDA Compliant \u2013 Meets global ophthalmic standards, including GMP, FDA 21 CFR Part 11, EU GMP, and ISO 13485; supports IQ\/OQ\/PQ validation, batch data logging, and full audit trail for regulatory compliance. \u2705 High-Precision Filling & Stoppering \u2013 Equipped with servo-driven ceramic\/peristaltic pumps, filling volume 0.1-50ml adjustable, filling accuracy \u2264\u00b10.5%; vacuum stoppering with 50-80N adjustable pressure, stoppering qualification rate \u226599.9% to ensure tight sealing and product integrity. \u2705 Intelligent Torque-Controlled Capping \u2013 Automatic cap feeding, positioning, and torque-adjustable capping (0.5-5N\u00b7m), ensuring consistent, tamper-resistant sealing; supports different cap types, capping qualification rate \u226599.8% with real-time torque data traceability. \u2705 Flexible & Efficient Production \u2013 Servo-driven system with quick format change (\u226430 minutes) for different bottle sizes and eye drop formulations; production capacity 1000-12000 bottles\/hour, adaptable to small-batch and large-scale production needs. \u2705 Easy Operation & Low Maintenance \u2013 PLC+HMI touch screen interface, with parameter one-click switching, recipe storage (up to 50+ recipes), and real-time production monitoring; contact parts made of 316L stainless steel (Ra\u22640.4\u03bcm), easy to disassemble, clean, and sterilize (SIP\/CIP compatible). \u2705 Advanced Quality Control \u2013 Built-in sensors for 100% in-process control (IPC), automatically detecting no-bottle no-filling, under-filling, missing stoppers, and cap misalignment, rejecting defective products to maintain consistent quality.<\/p>\n
1.Product Protection & Contamination Control (GMP) These features ensure the product remains sterile, unadulterated, and consistent from the first bottle to the last. Material Compatibility:<\/p>\n
1.1 Product-contact parts must be made of AISI 316L stainless steel, medical-grade silicone, or FDA-approved plastics to prevent chemical leaching and corrosion. 1.2 Sanitary Design: Machines require smooth surfaces, minimal crevices, and tri-clamp connections to eliminate areas where bacteria can grow. 1.3 CIP\/SIP Capabilities: Clean-in-Place (CIP) and Sterilization-in-Place (SIP) systems allow automated cleaning and steaming of fluid pathways without dismantling the machine. 1.4 Laminar Airflow & Isolation: RABS (Restricted Access Barrier Systems) or Isolators supply HEPA-filtered air to maintain a sterile zone over the open containers. 1.5 Drip and Splash Controls: Anti-drip nozzles and diving nozzles (which lower into the bottle during filling) prevent product from spilling onto the container rims, which could ruin the cap seal.<\/p>\n
2.1 Interlocked Physical Enclosures: Transparent polycarbonate or tempered glass doors prevent operators from reaching into moving parts. Opening a door instantly cuts power to the moving components. 2.2 Emergency Stop (E-Stop) Buttons: Highly visible, mushroom-headed buttons must be placed at multiple accessible points around the machine to halt operations immediately. 2.3 Capping Torque Control: Magnetic clutches or servo-driven capping heads prevent over-torqueing (which can shatter glass or strip plastic caps) and under-torqueing (which causes leaks). 2.4 Low Noise Levels: Sound-dampening enclosures keep noise levels below OSHA-mandated limits (usually under 85 dBA), especially around noisy cap-sorting bowls.<\/p>\n
3.1 Weight & Fill Verification: In-line checkweighers or vision systems instantly reject under-filled or over-filled containers without stopping the line. 3.2 Cap Detection Systems: Vision sensors detect missing, crooked, or high caps, automatically pushing faulty products to a rejection tray. 3.3 Audit Trails & 21 CFR Part 11: For pharmaceuticals, the machine\u2019s software must track all operator logins, setting changes, and alarms in a secure, unalterable electronic log.<\/p>\n
Shanghai Reliance Machinery Co., Ltd.\u00a0is a professional manufacturer of pharmaceutical liquid filling and packaging equipment, providing complete turnkey solutions for sterile liquid production.<\/p>\n
01 Specifications<\/p>\n
02 DESCRIPTION<\/p>\n
03 FEATURE<\/p>\n
04 FAQ<\/p>\n
05 GMP & SAFTY<\/p>\n
06 WHY RELIANCE<\/p>","protected":false},"excerpt":{"rendered":"
DESCRIPTION Ideal for sterile eye drop production in pharmaceutical, biotech, and ophthalmic industries, including preservative-free eye drops, artificial tears, dry […]<\/p>\n","protected":false},"featured_media":3356,"menu_order":0,"template":"","cxb_product_category":[8],"cxb_product_tag":[83],"class_list":["post-4524","cxb_products","type-cxb_products","status-publish","has-post-thumbnail","hentry","cxb_product_category-monoblock-filling-capping-machine","cxb_product_tag-ophthalmic"],"_links":{"self":[{"href":"https:\/\/28.feihuaweiye.com\/fr\/wp-json\/wp\/v2\/cxb_products\/4524","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/28.feihuaweiye.com\/fr\/wp-json\/wp\/v2\/cxb_products"}],"about":[{"href":"https:\/\/28.feihuaweiye.com\/fr\/wp-json\/wp\/v2\/types\/cxb_products"}],"version-history":[{"count":3,"href":"https:\/\/28.feihuaweiye.com\/fr\/wp-json\/wp\/v2\/cxb_products\/4524\/revisions"}],"predecessor-version":[{"id":6367,"href":"https:\/\/28.feihuaweiye.com\/fr\/wp-json\/wp\/v2\/cxb_products\/4524\/revisions\/6367"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/28.feihuaweiye.com\/fr\/wp-json\/wp\/v2\/media\/3356"}],"wp:attachment":[{"href":"https:\/\/28.feihuaweiye.com\/fr\/wp-json\/wp\/v2\/media?parent=4524"}],"wp:term":[{"taxonomy":"cxb_product_category","embeddable":true,"href":"https:\/\/28.feihuaweiye.com\/fr\/wp-json\/wp\/v2\/cxb_product_category?post=4524"},{"taxonomy":"cxb_product_tag","embeddable":true,"href":"https:\/\/28.feihuaweiye.com\/fr\/wp-json\/wp\/v2\/cxb_product_tag?post=4524"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}