{"id":4994,"date":"2026-10-08T20:25:49","date_gmt":"2026-10-08T20:25:49","guid":{"rendered":"https:\/\/28.feihuaweiye.com\/case-study-250ml-isoflurane-filling-capping-line-successfully-delivered-to-brazil\/"},"modified":"2026-11-07T06:51:32","modified_gmt":"2026-11-07T06:51:32","slug":"case-study-250ml-isoflurane-filling-capping-line-successfully-delivered-to-brazil","status":"publish","type":"post","link":"https:\/\/28.feihuaweiye.com\/ko\/case-study-250ml-isoflurane-filling-capping-line-successfully-delivered-to-brazil\/","title":{"rendered":"Case Study: 250ml Isoflurane Filling &amp; Capping Line Successfully Delivered to Brazil"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"4994\" class=\"elementor elementor-4994\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-51e7efc e-con-boxed e-flex e-con e-parent\" data-id=\"51e7efc\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-dc4db1d e-con-full e-flex e-con e-child\" data-id=\"dc4db1d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cb62028 e-con-boxed e-flex e-con e-parent\" data-id=\"cb62028\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-4dfb046 e-con-full e-flex e-con e-child\" data-id=\"4dfb046\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9b4533b elementor-widget elementor-widget-heading\" data-id=\"9b4533b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Case Study: 250ml Isoflurane Filling &#038; Capping Line Successfully Delivered to Brazil<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-323076a elementor-invisible elementor-widget elementor-widget-image\" data-id=\"323076a\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"850\" height=\"326\" src=\"https:\/\/28.feihuaweiye.com\/wp-content\/uploads\/2026\/09\/Inhalation_anesthetic_filling_capping_machine4-e1793678705472.png\" class=\"attachment-full size-full wp-image-4314\" alt=\"\" srcset=\"https:\/\/28.feihuaweiye.com\/wp-content\/uploads\/2026\/09\/Inhalation_anesthetic_filling_capping_machine4-e1793678705472.png 850w, https:\/\/28.feihuaweiye.com\/wp-content\/uploads\/2026\/09\/Inhalation_anesthetic_filling_capping_machine4-e1793678705472-300x115.png 300w, https:\/\/28.feihuaweiye.com\/wp-content\/uploads\/2026\/09\/Inhalation_anesthetic_filling_capping_machine4-e1793678705472-768x295.png 768w, https:\/\/28.feihuaweiye.com\/wp-content\/uploads\/2026\/09\/Inhalation_anesthetic_filling_capping_machine4-e1793678705472-18x7.png 18w\" sizes=\"(max-width: 850px) 100vw, 850px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-508741d elementor-widget elementor-widget-post-info\" data-id=\"508741d\" data-element_type=\"widget\" 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48.4-130.1 48.4zm162.7-84.1c-24.4-31.4-62.1-51.9-105.1-51.9-10.2 0-26 9.6-57.6 9.6-31.5 0-47.4-9.6-57.6-9.6-42.9 0-80.6 20.5-105.1 51.9C61.9 339.2 48 299.2 48 256c0-110.3 89.7-200 200-200s200 89.7 200 200c0 43.2-13.9 83.2-37.3 115.9z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-author\">\n\t\t\t\t\t\t\t\t\t\tadmin\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item- elementor-inline-item elementor-icon-list-item elementor-repeater-item- elementor-inline-item\" itemprop=\"author datePublished\">\n\t\t\t\t\t\t<a href=\"https:\/\/28.feihuaweiye.com\/ko\/author\/admin\/ https:\/\/28.feihuaweiye.com\/ko\/2026\/10\/08\/\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-calendar\" viewBox=\"0 0 448 512\" 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class=\"elementor-icon-list-item elementor-repeater-item- elementor-inline-item elementor-icon-list-item elementor-repeater-item- elementor-inline-item elementor-icon-list-item elementor-repeater-item- elementor-inline-item elementor-icon-list-item elementor-repeater-item- elementor-inline-item\" itemprop=\"author datePublished commentCount\">\n\t\t\t\t\t\t<a href=\"https:\/\/28.feihuaweiye.com\/ko\/author\/admin\/ https:\/\/28.feihuaweiye.com\/ko\/2026\/10\/08\/ https:\/\/28.feihuaweiye.com\/ko\/case-study-250ml-isoflurane-filling-capping-line-successfully-delivered-to-brazil\/#respond\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-comment-dots\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M144 208c-17.7 0-32 14.3-32 32s14.3 32 32 32 32-14.3 32-32-14.3-32-32-32zm112 0c-17.7 0-32 14.3-32 32s14.3 32 32 32 32-14.3 32-32-14.3-32-32-32zm112 0c-17.7 0-32 14.3-32 32s14.3 32 32 32 32-14.3 32-32-14.3-32-32-32zM256 32C114.6 32 0 125.1 0 240c0 47.6 19.9 91.2 52.9 126.3C38 405.7 7 439.1 6.5 439.5c-6.6 7-8.4 17.2-4.6 26S14.4 480 24 480c61.5 0 110-25.7 139.1-46.3C192 442.8 223.2 448 256 448c141.4 0 256-93.1 256-208S397.4 32 256 32zm0 368c-26.7 0-53.1-4.1-78.4-12.1l-22.7-7.2-19.5 13.8c-14.3 10.1-33.9 21.4-57.5 29 7.3-12.1 14.4-25.7 19.9-40.2l10.6-28.1-20.6-21.8C69.7 314.1 48 282.2 48 240c0-88.2 93.3-160 208-160s208 71.8 208 160-93.3 160-208 160z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-author elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-date elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-time elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-comments\">\n\t\t\t\t\t\t\t\t\t\tNo Comments\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7ab156d elementor-widget elementor-widget-text-editor\" data-id=\"7ab156d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t\n<p>Reliance Machinery recently completed the installation and commissioning of a <span style=\"color: #993300;\"><strong><b>250ml Isoflurane Filling &amp; Capping Line<\/b><\/strong><\/span>\u00a0for a leading pharmaceutical manufacturer in Brazil. The project was designed for the automatic filling, capping, and inspection of volatile inhalation anesthetics, ensuring high accuracy, operator safety, and full compliance with GMP requirements.<\/p>\n<p>The customer required a reliable production line capable of handling 250ml amber glass bottles containing isoflurane while maintaining product quality and minimizing anesthetic vapor exposure throughout the production process.<\/p>\n<h4><strong>Customer Requirements<\/strong><\/h4>\n<p>The Brazilian pharmaceutical company had several key objectives:<\/p>\n<ul>\n<li>High filling accuracy for 250ml Isoflurane bottles<\/li>\n<li>Closed filling system to reduce anesthetic evaporation<\/li>\n<li>Automatic cap feeding and torque-controlled capping<\/li>\n<li>Stable production with minimal downtime<\/li>\n<li>GMP-compliant design for pharmaceutical manufacturing<\/li>\n<li>Easy cleaning and maintenance<\/li>\n<li>Future integration with labeling and packaging equipment<\/li>\n<\/ul>\n<p>After technical discussions, Reliance Machinery engineered a customized\u00a0<strong><b>Isoflurane Filling &amp; Capping Line<\/b><\/strong><strong><b>\u00a0<\/b><\/strong>tailored to the customer\u2019s production process.<\/p>\n<h4><strong>Equipment Configuration<\/strong><\/h4>\n<p>The complete production line includes:<\/p>\n<ul>\n<li>Automatic bottle unscrambler (optional)<\/li>\n<li>Bottle infeed conveyor<\/li>\n<li>Automatic bottle positioning system<\/li>\n<li>High-precision liquid filling machine<\/li>\n<li>Automatic cap feeder<\/li>\n<li>Servo-controlled capping machine<\/li>\n<li>Bottle inspection station<\/li>\n<li>Reject system<\/li>\n<li>Collection conveyor<\/li>\n<\/ul>\n<p>The system is designed specifically for 250ml amber glass bottles used in inhalation anesthetic packaging.<\/p>\n<h4><strong>Technical Specifications\uff1a<\/strong><\/h4>\n<table>\n<tbody>\n<tr>\n<td>Item<\/td>\n<td>Specification<\/td>\n<\/tr>\n<tr>\n<td>Product<\/td>\n<td>Isoflurane<\/td>\n<\/tr>\n<tr>\n<td>Bottle Size<\/td>\n<td>250ml Amber Glass Bottle<\/td>\n<\/tr>\n<tr>\n<td>Filling Accuracy<\/td>\n<td>\u00b10.5%<\/td>\n<\/tr>\n<tr>\n<td>Filling System<\/td>\n<td>Ceramic Piston Pump<\/td>\n<\/tr>\n<tr>\n<td>Capacity<\/td>\n<td>Up to 40 Bottles\/Minute<\/td>\n<\/tr>\n<tr>\n<td>Cap Type<\/td>\n<td>Screw Cap<\/td>\n<\/tr>\n<tr>\n<td>Control System<\/td>\n<td>Siemens PLC + Siemens HMI<\/td>\n<\/tr>\n<tr>\n<td>Drive System<\/td>\n<td>Servo Motor<\/td>\n<\/tr>\n<tr>\n<td>Machine Material<\/td>\n<td>SUS304 \/ SUS316L<\/td>\n<\/tr>\n<tr>\n<td>Compliance<\/td>\n<td>GMP<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h4><\/h4>\n<h4><\/h4>\n<h4><strong>Key Features of the Isoflurane Filling Line<\/strong><\/h4>\n<h5><strong>High Filling Accuracy<\/strong><\/h5>\n<p>Isoflurane is an expensive pharmaceutical anesthetic, making dosing precision critical. The ceramic piston filling system delivers consistent filling volumes while minimizing product waste.<\/p>\n<h5><strong>Closed Filling Design<\/strong><\/h5>\n<p>Because isoflurane is volatile, the filling station features a closed design that helps reduce vapor loss and improves workplace safety.<\/p>\n<h5><strong>Intelligent No-Bottle-No-Fill Function<\/strong><\/h5>\n<p>Photoelectric sensors ensure that bottles are correctly positioned before filling begins. If no bottle is detected, the machine automatically skips the filling cycle.<\/p>\n<h5><strong>Servo-Controlled Capping<\/strong><\/h5>\n<p>The servo capping system applies precise and consistent torque, ensuring secure sealing without damaging caps or bottles.<\/p>\n<h4><strong>Automatic Inspection and Rejection<\/strong><\/h4>\n<p>The production line automatically detects:<\/p>\n<ul>\n<li>Missing bottles<\/li>\n<li>Missing caps<\/li>\n<li>Crooked caps<\/li>\n<li>Improperly sealed bottle<\/li>\n<\/ul>\n<p>Defective products are rejected automatically without interrupting production.<\/p>\n<h4><strong>GMP-Oriented Design<\/strong><\/h4>\n<p>The entire line was designed according to pharmaceutical GMP standards.<\/p>\n<p>Key GMP features include:<\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"44\">1<\/td>\n<td width=\"524\">Stainless steel SUS304\/SUS316L construction<\/td>\n<\/tr>\n<tr>\n<td width=\"44\">2<\/td>\n<td width=\"524\">Hygienic machine design with smooth surfaces<\/td>\n<\/tr>\n<tr>\n<td width=\"44\">3<\/td>\n<td width=\"524\">Easy cleaning and maintenance<\/td>\n<\/tr>\n<tr>\n<td width=\"44\">4<\/td>\n<td width=\"524\">Minimal dead corners<\/td>\n<\/tr>\n<tr>\n<td width=\"44\">5<\/td>\n<td width=\"524\">Validation-ready architecture<\/td>\n<\/tr>\n<tr>\n<td width=\"44\">6<\/td>\n<td width=\"524\">Electronic production data support<\/td>\n<\/tr>\n<tr>\n<td width=\"44\">7<\/td>\n<td width=\"524\">Optional 21 CFR Part 11 compliance<\/td>\n<\/tr>\n<tr>\n<td width=\"44\">8<\/td>\n<td width=\"524\">Optional Audit Trail and electronic records<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h4><\/h4>\n<h4><strong>Challenges and Solutions\uff1a<\/strong><\/h4>\n<h4><strong>Challenge 1: Handling Volatile Liquids<\/strong><\/h4>\n<p>Isoflurane evaporates easily during production.<\/p>\n<p><span style=\"color: #993300;\"><strong><b>Solution:<\/b><\/strong><\/span><\/p>\n<p><span style=\"color: #800000;\">Reliance Machinery designed a sealed filling system that significantly reduces evaporation while maintaining filling accuracy.<\/span><\/p>\n<h4><strong>Challenge 2: Preventing Bottle Damage<\/strong><\/h4>\n<p>Amber glass bottles are relatively fragile.<\/p>\n<p><span style=\"color: #993300;\"><strong><b>Solution:<\/b><\/strong><\/span><\/p>\n<p><span style=\"color: #800000;\">Servo-controlled bottle indexing ensures smooth transportation without collision.<\/span><\/p>\n<h4><strong>Challenge 3: Maintaining Stable Torque<\/strong><\/h4>\n<p>Different batches of caps may require slight torque adjustments.<\/p>\n<p><span style=\"color: #993300;\"><strong><b>Solution:<\/b><\/strong><\/span><\/p>\n<p><span style=\"color: #800000;\">The servo capping system allows operators to adjust torque directly from the HMI without mechanical changes.<\/span><\/p>\n<h4><strong>Customer Benefits<\/strong><\/h4>\n<p>After installation, the Brazilian customer achieved several operational improvements:<\/p>\n<ul>\n<li>Increased production efficiency<\/li>\n<li>Reduced product loss<\/li>\n<li>Improved filling consistency<\/li>\n<li>Lower labor requirements<\/li>\n<li>Stable long-term operation<\/li>\n<li>Easier GMP documentation and validation<\/li>\n<\/ul>\n<p>The customer also praised the machine\u2019s user-friendly interface, low maintenance requirements, and responsive after-sales technical support.<\/p>\n<h4><strong>Why Choose Reliance Machinery?<\/strong><\/h4>\n<p>Reliance Machinery specializes in pharmaceutical liquid filling equipment, including solutions for sterile and non-sterile products.\u00a0Our expertise includes:<\/p>\n<ul>\n<li>Isoflurane Filling Machines<\/li>\n<li>Inhalation Anesthetic Filling Lines<\/li>\n<li>Eye Drop Filling Machines<\/li>\n<li>Oral Spray Filling Machines<\/li>\n<li>Nasal Spray Filling Machines<\/li>\n<li>Sterile Liquid Filling Systems<\/li>\n<li>Pharmaceutical Bottle Filling &amp; Capping Machines<\/li>\n<\/ul>\n<p>Every project is customized according to bottle size, filling volume, production capacity, and regulatory requirements.<\/p>\n<h4><strong>Conclusion<\/strong><\/h4>\n<p>This successful 250ml Isoflurane Filling &amp; Capping Line project in Brazil demonstrates Reliance Machinery\u2019s ability to deliver reliable, GMP-compliant pharmaceutical filling solutions for volatile anesthetic products.<\/p>\n<p>Whether you require a standalone filling machine or a complete turnkey production line, our engineering team can provide customized solutions that improve productivity, product quality, and operational efficiency.<\/p>\n<p>Looking for a reliable Isoflurane Filling Machine or Inhalation Anesthetic Filling Line? 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